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KMID : 0388019930040010056
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Korean Journal Gynecologic Oncology and Colposcopy
1993 Volume.4 No. 1 p.56 ~ p.65
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Prognostic Value of Nucleolar Organizer Regions in Invasive Cervial Carcinoma
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송용상
박중신/전혜원/김병기/김종훈/최영민/강순범/이효표/김우호
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Abstract
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We evaluated 17 women with normal cervix and 67 women with invasive cervical carcinoma to determine the relationship between the clinical variables of the cervical cancer(age, clinical stage, tumor size, depth of invasion, 5-year disease free
survival
rate) and nucleolar organizer regions by silver colloid technique with formalin fixed paraffin embedded tissues from January 1985 to December 1986.
We calculated the mean number of AgNORs per cell among 100 cells using an oil immersion lens and classified two groups according to the mean number of AgNOR, 1.5(group II>1.5). There was significantly higher number of AgNOR s in the invasive
cervical
carcinoma than in the normal cervix(Mean+SEN: 1.20+0.15, 1.65+0.06). The number of AgNORs was not significantly associated with age. tumor size, depth of invasion and clinical stage. And there was no significant significant difference in the
5-year
disease free survival rates between the two groups in invasive cervical carcinoma.
So we concluded that the number of AgNOR may be useful for the differential diagnosis between the normal and the malignancy but may not be useful as the prognostic factor of cervical carcinoma.
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KEYWORD
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